Male Pattern Baldness Is A Cure in Sight…

Male Pattern Baldness, Is A Cure in Sight?

Does Prostaglandin D2 stop hair growth in men with male pattern baldness as research claims? This paper seeks to prove that Prostaglandin D2 is a cure for male pattern baldness.
What is Prostaglandin? The Columbia Encyclopedia, 6th Ed. says,
“(P)rostaglandins, are any of a group of about a dozen compounds synthesized from fatty acids in mammals as well as in lower animals. Prostaglandins are highly potent substances that are not stored but are produced as needed by cell membranes in virtually every body tissue. Different prostaglandins have been found to raise or lower blood pressure and regulate smooth muscle activity and glandular secretion…”
‘Hair loss (alopecia) can affect just your scalp or your entire body.
• It can be the result of heredity
• certain medications
• or any underlying medical condition
Anyone — men, women and children — can experience hair loss. Baldness typically refers to excessive hair loss from your scalp. Some people prefer to let their baldness run its course untreated and unhidden. Others may cover it up with hairstyles, makeup, hats or scarves. And still others choose one of the medications or surgical procedures that are available to treat hair loss.”
Shaved heads in America have become an accepted style for men from adolescence to middle age, and older. This style became popular when Michael Jordan shaved his head during his days with the Chicago Bulls.
So, biologically what causes hair loss? The consensus to PGD2 is that it usually inhibits hair growth. The reason: PGD2 levels are elevated in men, women and also lab mice that exhibit hair loss.
Researchers report that Prostaglandin levels were 3 times greater than what is found in haired scalps of “men and women with androgenic alopecia (Kashmir).”
Note: some are derivatives of Prostaglandin; they are GPR44, D2, and 15-DPG12, to name a few. They perform differently under different circumstances and with combinations of other chemicals.
What do critics and others think of the impact of Prostaglandin D2? Critics have discovered that Prostaglandin D2 is potentially a newly discovered pathway to curing male pattern baldness.
Lab results prove that when PGD2 is added to “cultured hair follicles the PGD2 treated hair is significantly shorter, while its derivative, 15-DPG12, completely inhibited hair growth.” In an article abstract the details of Prostaglandin D2 are explained,
“Title: Prostaglandin d2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.
Author: Garza, Luis A
Liu, Yaping ; Yang, Zaixin ; Alagesan, Brinda ; Lawson, John A ; Norberg, Scott M ; Loy, Dorothy E ; Zhao, Tailun ; Blatt, Hanz B ; Stanton, David C ; Carrasco, Lee ; Ahluwalia, Gurpreet ; Fischer, Susan M ; Fitzgerald, Garret A ; Cotsarelis, George
Is Part Of: Sci Transl Med; Volume: 4, Issue: 126, Date: 2012 Mar 21, Pages: 126ra34
Description: Testosterone is necessary for the development of male pattern baldness, known as androgenetic alopecia (AGA); yet, the mechanisms for decreased hair growth in this disorder are unclear. We show that prostaglandin D(2) synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA. The product of PTGDS enzyme activity, prostaglandin D (2) (PGD(2)), is similarly elevated in bald scalp. During normal follicle cycling in mice, Ptgds and PGD (2) levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD(2) inhibits hair growth in explanted human hair follicles and when applied topically to mice. Hair growth inhibition requires the PGD (2) receptor G protein (heterotrimeric guanine nucleotide)-coupled receptor 44 (GPR44), but not the PGD (2) receptor 1 (PTGDR). Furthermore, we find that a transgenic mouse, K14-Ptgs2, which targets prostaglandin-endoperoxide synthase 2 expression to the skin, demonstrates elevated levels of PGD(2) in the skin and develops alopecia, follicular miniaturization, and sebaceous gland hyperplasia, which are all hallmarks of human AGA. These results define PGD (2) as an inhibitor of hair growth in AGA and suggest the PGD (2)-GPR44 pathway as a potential target for treatment.
Language: English
Creation Date: 2012”

The significance of this discovery is that a “cure” for male pattern baldness is potentially a reality in the near future. The discovery will have a world-wide impact.
Hair loss is not solely a “male” condition or disorder; it is prevalent in females as well due to various health issues. Therefore it is potentially a highly profitable discovery.
“Researchers found that PGD2 inhibits hair growth, other prostaglandins may or can work in opposition, enhancing and regulating the speed of hair growth (Cure, Kashmir 2012)… or theoretically, restricting the D2 derivative from inhibiting growth, is possibly the pathway of the researchers.
Balance and Counter Balance: A Possible approach to a hair loss remedy
What precautions might be taken to make sure that a potential drug to block the hair loss drug would not interfere with the positive effects of PGD (2) in the body?”
One precaution is to insure that the positive “drug” PGE2, is enhanced while the “drug” PGD2 is simultaneously decreased to produce the desired result;
“Our results suggest that in mouse and human skin, a balance between PGE2 and PGD2 controls hair growth. This model predicts then that efforts to reverse alopecia should optimally focus on both enhancing PGE2 and inhibiting PGD2 signaling (See footnote link for, (16) “Our results suggest…).”

To answer the thesis question, is Prostaglandin D2 a cure for male pattern baldness? The evidence suggests that balancing the two versions of Prostaglandins is the primary catalyst to affecting hair growth in a manner that positively allows for positive hair growth in men and women;
“…Additional evidence that prostaglandins control hair follicle cycling and can be used therapeutically to treat AGA arises from findings on the possible mechanism of the AGA drug minoxidil. Although minoxidil alters potassium channel kinetics (7), it is also known to increase production of PGE2 (37). Given the decreased amount of PGE2 present in bald scalp versus haired scalp (Fig. 2E), minoxidil may normalize PGE2 levels. Future studies should address whether minoxidil can concomitantly decrease PGD2 levels and thus normalize multiple prostaglandin species as a mechanism to improve AGA.”

Hair loss affects 8 to 10 men under 70 years of age (cure, 2012).” The implication of PGD2’s inhibition qualities is that when it is chemically “related through its receptor GPR44 it becomes a “promising therapeutic target for androgenic alopecia in both men and women with hair loss or thinning (cure,).”
Prostaglandins are naturally produced in the body some in a myriad of uses including treatments for asthma, and cancer.
Finally, although researchers are fairly optimistic about male pattern baldness becoming a thing of the past; I am less enthusiastic because according to George Cotsarelis, MD, chair and Professor of Dermatology, Perelman School of Medicine at the University of Pennsylvania;
“our findings were unexpected as prostaglandins haven’t been thought about in relation to hair loss, yet it made sense that there was an inhibitor of hair growth, based on our earlier work looking at hair follicle stem cells (cure).”

A cure is actually down the road in my estimate at least ten years. For the 8-10 men under 70 years old including women this study offers hope; hair loss is a cosmetic problem but it affects self-esteem and confidence. Therefore it is potentially important to humanities affect as a positive thriving community.

Works Cited

1. What is Prostaglandin?
http://www.sciencenews.org/view/generic/id/339308/title/The_yin_and_yang_of_male_pattern_baldness.

2. Source: “prostaglandin.” The Columbia Encyclopedia, 6th ed.. 2011. Encyclopedia.com. 12 Apr. 2012 .

3. Hair Loss-Alopecia
Source: http://www.mayoclinic.com/health/hair-loss/DS00278

4. “Additional evidence that prostaglandins control hair follicle cycling.”

http://www.ncbi.nlm.nih.gov/pubmed/3278714.
http://www.ncbi.nlm.nih.gov/pubmed/17702866.

http://www.ncbi.nlm.nih.gov/pubmed/3278714.

A note of clarification

I have posted school writing assignments to try and boost reader interest.  I am graduating soon, on 5/5/12 and expect my content to reflect that change.  I will again try and add interesting content to my site.  

And I expect the topics to reflect a more relevant subject matter (at least I hope that is what will happen) anyway please continue to drop by and leave a comment or request for me to research.  I will enjoy the challenge!

Grace and peace to all of you.

Steve spain